Methylfolate Trap Explained in Cobalamin Deficiency | NEET PG GOLD
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Methylfolate Trap Explained in Cobalamin Deficiency | NEET PG GOLD
The methylfolate trap is a key biochemical event in vitamin B₁₂ (cobalamin) deficiency. When vitamin B₁₂ is absent, folate becomes trapped as 5-methyl-tetrahydrofolate, blocking DNA synthesis and causing a functional folate deficiency — even if folate levels appear normal. This mechanism explains why B₁₂ deficiency leads to ...
228 views6 months ago
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