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Hematology refresher on monoclonal gammopathy. 🩸 differential diagnosis includes MGUS, smoldering myeloma, multiple myeloma, amyloidosis. 🩸 it’s defined as a monoclonal protein without end organ damage (CRAB-SLiM). 🩸 there is a 1% chance per year risk of progression to multiple myeloma. 🩸 don’t forget about the rare associations: MG of renal significance, neuropathy, osteoporosis. 🩸 we do not have a cure so we recommend active surveillance, also known as expected monitoring: CBC, CMP, SIFE.
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