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The TCA Cycle, Citrate & Lipid Biosynthesis @Metabolism Made Easy
In the well-fed state, the TCA cycle can be inhibited by elevated levels of ATP and NADH at the Isocitrate Dehydrogenase step, resulting in the accumulation of citrate in the mitochondrial matrix. Citrate transport out of the mitochondria will then be hydrolyzed to provide the acetyl CoA needed in the cytoplasm for both fatty acid and ...
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