This fundamental work demonstrates that compartmentalized cellular metabolism is a dominant input into cell size control in a variety of mammalian cell types and in Drosophila. The authors show that ...

FDA grants a Type A meeting on December 18th to review new and expanded datasets submitted by Saol to help identify a feasible path forward without the need for an additional clinical trial ROSWELL, ...

JACKSONVILLE, Fla. — The parents of four-year-old Harlow Higbee say they fear a treatment that has dramatically improved their daughter’s quality of life could soon be cut off for her and other ...

The Company is currently seeking a path forward with the FDA that would not require an additional clinical trial. The Food and Drug Administration (FDA) has issued a Complete Response Letter (CRL) to ...

GRAND RAPIDS, Mich. — For families of children with pyruvate dehydrogenase complex deficiency (PDCD), a rare metabolic disorder, hope is tied to one drug: DCA. The treatment is given orally and works ...

After receiving a complete response letter for its pyruvate dehydrogenase complex deficiency candidate, Saol Therapeutics anticipates it will need “several years” and “significant financial resources” ...

A Michigan woman has shared dramatic footage of the moment her uterus began to rupture. Holly Cieslinski, from Grand Rapids, shared footage to TikTok @hollycski of the moment she lent over her ...

6-PPDQ, has emerged as an environmental concern due to its widespread detection and toxic effects. In a study published in Environmental Chemistry and Ecotoxicology, researchers from Southeast ...

ABSTRACT: Skeletal muscle is the largest organ in the human body, and improving energy metabolism is crucial for maintaining and promoting health, including alleviating metabolic disorders like ...

Ethylene plays its essential roles in plant development, growth, and defense responses by controlling the transcriptional reprograming, in which EIN2-C-directed regulation of histone acetylation is ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Defects in mitochondrial oxidative metabolism ...

Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is a genetic condition that prevents the body from breaking down fat stores for energy. It can be fatal without early diagnosis and treatment.