The 7-week-old male C57BL/6J mice were acquired from the Nanjing Model Animal Research Center and kept in the SPF animal laboratory (temperature of 22 °C ± 2 °C under a 12-h light/dark cycle) with ...

Atossa Therapeutics (ATOS) announced that the U.S. FDA issued a “Study May Proceed” letter for the company’s study in metastatic breast cancer ...

The intestinal epithelium undergoes rapid renewal every 3–5 days, a process driven by intestinal stem cells (ISCs) located at the base of crypts. While ISCs play an essential role in epithelial ...

DPTX3186, a condensate modulating agent, targets the Wnt/β-catenin pathway, crucial in gastric cancer progression, by sequestering β-catenin in a drug-induced condensate. FDA fast track designation ...

Angiotensin II (Ang II)* is a multifunctional hormone that influences the function of cardiovascular cells through a complex series of intracellular signaling events initiated by the interaction of ...

In a groundbreaking review published in Current Molecular Pharmacology, researchers from Teerthanker Mahaveer University have mapped the molecular mechanisms behind diabetic neuropathy and nephropathy ...

This study by Nakahara et al. (DOI: 10.1021/acsmedchemlett.5c00214) investigates the impact of the oxygen atom position in the linear side chains of hydrobenzopyran-based ansellone analogues on HIV ...

Diabetic retinopathy (DR) is a common and severe microvascular complication of diabetes, leading to vision impairment and blindness, particularly in working-age adults. Oxidative stress plays a ...