Get the latest preview, odds, best bets, probable lineups, and injury updates for the upcoming San Francisco 49ers vs. Seattle Seahawks game.

SportsLine has an expansive team of NFL experts who provide quality betting advice for every game on the schedule. Insider Jason La Canfora has revealed three best bets for Week 6, including the ...

The Arizona Cardinals pulled off a massive upset in Week 5, erasing a double-digit deficit to beat the San Francisco 49ers.  The win moved the Cardinals to 2-3 ...

There was little chance of topping the action-packed week 4 that saw four former Virginia football players deliver incredible ...

Minnesota Vikings running back Aaron Jones is considered week-to-week due to a hip injury, coach Kevin O'Connell said on ...

Let the Drake Maye era begin. The New England Patriots will promote the rookie quarterback to the starting post over Jacoby Brissett for Sunday's game ...

T he Seattle Seahawks were 3-0 heading into Week 4, but stumbled against the Detroit Lions, but despite the loss, most ...

The Seahawks host the 49ers on Thursday Night! We now continue our NFL odds series with a 49ers-Seahawks prediction and pick.