Lionel Messi departed Inter Miami's matchup with Necaxa in the 2025 Leagues Cup on Saturday with a hamstring injury, head coach Javier Mascherano told reporters after the team's win on penalties.

Lionel Messi knew he was injured the moment he tripped and fell on the pitch, rolling over to slap the ground in frustration. Messi slowly walked from the penalty area across midfield, in front of Inter Miami’s bench as his frustration slowly boiled over.

Lionel Messi left injured in the 11th minute with hamstring discomfort, but Inter Miami earned a 5-4 penalty shootout win against visiting Necaxa following a 2-2 draw in Matchday 2 of Leagues Cup Phase One play on Saturday night.