Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the GI tract. The two major types of IBD are Crohn's disease (CD) and ulcerative colitis (UC). Whereas in UC inflammation ...

Trained immunity enhances innate immune responses, yet a Western lifestyle may lead to maladaptive trained immunity and drive ...

Phospholipases PLA1, PLA2, PLC, and PLD hydrolyze phospholipids to produce corresponding lysophospholipids and fatty acids. Red arrows indicate the corresponding hydrolysis sites. B) Phospholipases ...

Trained immunity provides a unifying framework linking innate immune memory to both protective and maladaptive inflammation ...

Very early in the COVID-19 pandemic clinical trials in patients hospitalized with COVID-19 confirmed that corticosteroids like dexamethasone reduced mortality, but they were harmful when applied at ...

1 Department of Internal Medicine, Division of Rheumatology, University of New Mexico, Albuquerque, NM 2 Biomedical Research Institute of New Mexico, Albuquerque, NM 3 Department of Molecular Genetics ...

Brain tissue analysis of an animal model has revealed the potential role of immune system dysfunction in the onset and progression of Alzheimer's disease (AD). Published April 15, 2025 in the Journal ...

A study has traced immune activity at high resolution in the first living recipient of a gene-edited pig kidney and has reported that – even after clinicians suppressed T-cell rejection – ...

Overview Key Takeaways: Your immune system is your body’s built-in defense network, working nonstop to protect you from bacteria, viruses, and other harmful invaders. Your immune … ...