Vesicoureteral reflux (VUR), retrograde flow of urine from bladder into kidneys, is present in ~1% of children in North America (1). Although VUR appears to follow an autosomal-dominant inheritance ...

To evaluate the effects of FGF-3 expression in the prostate and male reproductive tract, we employed a bitransgenic system to target FGF-3 to these organs. We present a first study that ectopic FGF-3 ...

Yao's team compared normal (wild type) and mutant embryonic development of the Wolffian duct (purple duct in the images) in the mouse. At day 15.5, no notable differences are visible, but two days ...

In most organs of the body, epithelial tissues are supported by their own basement membrane and underlying stroma, the latter being regarded as a complex of amorphous cells, extracellular matrices, ...

The Royal Society is a self-governing Fellowship of many of the world's most distinguished scientists drawn from all areas of science, engineering and medicine, and is the oldest scientific academy in ...

Going against the general consensus, scientists have unveiled an unexpected mechanism for sexual differentiation of critical reproductive structures during embryonic development. Every mammalian ...

Human sperm cells travel up to 6 meters in their transit from testes to penis, and most of that journey occurs in the epididymis, a tightly coiled tube that primes the cells for their ultimate task: ...

The testes cords, which contain the germ cells, are now connected to the Wolffian duct. Much later, during puberty, the germ cells will differentiate into sperm. After puberty, the testes will produce ...

Q: Which doctor should I consult for ambiguous genitalia? A: Ambiguous genitalia are treated by a team of doctors which often include pediatric surgeon, geneticist, endocrinologist and psychiatrist as ...