Repeat proteins, defined by sequential arrays of short structural motifs, offer an intriguing departure from the folding behaviour of conventional globular proteins. Their modular architecture enables ...
Protein hydrophobicity is a fundamental driver of protein folding dynamics, underpinning the formation of a central hydrophobic core that stabilises the three-dimensional structure amid an aqueous ...
In Alzheimer's, brain cells die too soon. In cancer, dangerous cells don't die soon enough. That's because both diseases alter the way cells decide when to end their lives, a process called programmed ...
While many businesses continue to seek AI’s killer app, biochemists have already found it. That application is protein folding. This week marks the five-year anniversary of the debut of Alpha Fold 2, ...
Randal Halfmann at the Stowers Institute for Medical Research in Kansas City is hoping to treat diseases including cancer and Alzheimer's by influencing how cells make life-or-death decisions. In ...
Scientists organize millions of proteins by shape, as predicted by AI, revealing 700,000 new families and some shapes unique ...
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Calcium signaling helps maintain protein quality in the endoplasmic reticulum
Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...
Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...
Scientists are hoping to treat diseases including cancer and Alzheimer's by influencing how cells make life-or-death decisions. In Alzheimer's, brain cells die too soon. In cancer, dangerous cells don ...
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