Scientists determined the cryo-EM structure of IGF Ternary complex and its assembly and activation mechanism. Insulin-like growth factor (IGF) is a hormone that greatly influences growth in fetuses ...
Protein-protein interactions are essential for maintaining cell structure and for executing almost all cellular processes. Determination of where and how each protein interacts with its partners ...
Metazoan replication-dependent histone messenger RNAs (mRNAs) have a conserved stem-loop (SL) at their 3′-end. The stem-loop binding protein (SLBP) specifically recognizes the SL to regulate histone ...
Chromatin is the complex of DNA and proteins that makes up the genetic material in the nucleus of eukaryotic cells. A chromatin modifier is a protein or complex of proteins that chemically modifies ...
Molecular glues are revolutionizing cancer therapy by targeting undruggable proteins for degradation, enhancing precision ...
"It is this ternary complex that is MDP's superb shield against the effects of radiation," said Northwestern's Brian Hoffman, who conducted the study with USU's Michael Daly. "We've long known that ...
Insulin-like growth factor (IGF) is a hormone that greatly influences growth in fetuses and children, but also body maintenance and metabolism in adults. IGF regulates cell proliferation, ...
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