C5aR1 expression correlates with increased metastasis risk and poor survival in cSCC patients. The tumor microenvironment, especially fibroblasts, influences C5aR1 expression and cSCC progression.
Abbreviations: 2D, two dimensional radiotherapy; 3D, three dimensional radiotherapy; CRT, chemoradiation; IMRT, intensity-modulated radiotherapy; RT, radiotherapy; VMAT, volumetric modulated arc ...
KEYNOTE-689 trial showed significant improvement in event-free survival for stage 3 or 4A resected head and neck squamous cell carcinoma with Keytruda. Keytruda regimen included neoadjuvant therapy, ...
Drug approvals this year have reflected the trend in clinical development of biologics shifting from intravenous to ...
Enfortumab vedotin and pembrolizumab showed a 39% overall response rate in recurrent/metastatic HNSCC with PD-L1 CPS ≥1. The trial reported a 9.8% complete response rate and a 29.3% partial response ...
Phase II Dose-Randomized Study of Sunvozertinib in Platinum-Pretreated Non–Small Cell Lung Cancer With Epidermal Growth Factor Receptor Exon 20 Insertion Mutations (WU-KONG1B) Patients with unresected ...
Keytruda plus platinum-based chemotherapy was found to be both safe and efficacious in treating penile squamous cell carcinoma (PSCC), according to findings from the phase 2 HERCULES trial presented ...
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