Orientation and positioning of the mitotic spindle are involved in dictating cell division axis and cleavage site, and play important roles in cell fate determination and tissue morphogenesis. However ...

Scientists have a solid understanding of what makes up spindles — the cellular machinery that separates chromosomes — but are less certain about how the building blocks of spindles, called ...

When a cell divides, it performs a feat of microscopic choreography—duplicating its DNA and depositing it into two new cells.

Production of Ran-guanosine triphosphate (GTP) around chromosomes induces local nucleation and plus end stabilization of microtubules (MTs). The nuclear protein TPX2 is required for RanGTP-dependent ...