Bisulfite conversion of genomic DNA combined with next-generation sequencing (BS-seq) is widely used to measure the methylation state of a whole genome, the methylome, at single-base resolution.
Recent advances in sequencing techniques have allowed whole genome sequencing to become more common and quicker. Whole genome bisulfite sequencing (WGBS) is one such next generation sequencing ...
DNA methylation is an epigenetic mechanism to regulate gene expression and involves adding a methyl group to a cytosine base. Abnormal methylation patterns have been associated with several conditions ...
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