Thymocyte selection and differentiation requires extracellular signal–regulated kinase (Erk) signaling, but transcription factor substrates of Erk in thymocytes are unknown. We have characterized the ...

(Note: After an award-winning career in the media business covering the tech industry, Bob Evans was VP of Strategic Communications at SAP in 2011, and Chief Communications Officer at Oracle from 2012 ...

The extracellular domain of SAP-1 extends into the intestinal lumen and its active tyrosine phosphatase domain resides in the cytoplasm. SAP-1 is thought to inhibit the development of colitis by ...

SAP-1 (stomach cancer-associated protein tyrosine phosphatase-1) is a transmembrane-type protein tyrosine phosphatase that has been implicated as a negative regulator of integrin-mediated signaling.