A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled receptors in living cells actually respond to activating substances. The ...

Resolving the mechanism of RXR ligand-dependent NR4A-RXR nuclear receptor heterodimer activation requires a diverse ligand set that includes heterodimer-selective agonists.

Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function. 'This study shows the dominant assemblies and states of the GABA receptor. That ...

Researchers have revealed how the thromboxane A₂ receptor is activated, which could help to inform future heart and lung drug ...

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...

A new study designs drugs that bind to intrinsically disordered proteins that are extremely difficult to target due to their flexible nature.

Summary: For over a century, potassium ions were viewed as mere passengers in the brain—particles that flow through channels ...

Cells are enveloped by a lipid membrane that gives them structure and provides a barrier between the cell and its environment ...