Matthew Stafford passes for 280 yards and four touchdowns as the Rams defeat the 49ers 42-26 to set up an NFC West showdown with the Seattle Seahawks next week.

The New Orleans Saints take on the Los Angeles Rams in a big game for rookie Tyler Shough. This is the place to keep up with the score and live updates from Inglewood, California.

Each Sunday, three of The Athletic’s NFL writers react to the biggest news, plays and performances from the day’s games.

The Los Angeles Rams face the San Francisco 49ers in an NFL game on Sunday, Nov. 9, 2025 at Levi’s Stadium in Santa Clara, California.

What are your Los Angeles Rams (5-2) versus the New Orleans Saints (1-7) final score predictions? I am picking the Rams in this one, and I want to keep my prediction grounded, but in theory, this game could (and maybe should?) get out of hand in favor of the Rams, but I’ll keep my prediction Rams 27, Saints 10.

The back half of the Indianapolis Colts' schedule appears to be tougher than its start. Here's who the Colts face the rest of the season.