These iPS cells enabled the recapitulation of the disease in vitro; an impaired differentiation into the pituitary. The causal gene mutation was identified in the patient by exome sequencing analysis.

We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. Back to Healio The COVID-19 pandemic presents ...

Since 2005, the Cleveland Clinic Foundation has held an annual symposium addressing contemporary issues in pituitary disease. The faculty includes Cleveland Clinic Foundation staff, physicians and ...

Pituitary tumors exhibit a spectrum of biology, with variable growth and hormonal behaviors. They therefore provide an opportunity to examine pathogenetic mechanisms that underlie the neoplastic ...

>Successfully created the world's first model of pituitary disease using human iPS cells. >iPS cells were generated from a patient with CPH. These iPS cells enabled the recapitulation of the disease ...

Please provide your email address to receive an email when new articles are posted on . Most adults with free thyroxine levels slightly below the reference range have normal free T 4 index values and ...

All patients found to have pituitary function defects underwent MRI of the hypothalamic–pituitary region. Outcome measures The main outcome measures were the prevalence of APA-positivity and the ...

The pituitary gland is located at the base of the brain, just below the hypothalamus, which regulates pituitary endocrine secretion. The gland consists of two main regions: the anterior pituitary ...

A recent Nature Medicine study showed that recipients of cadaver-derived pituitary growth hormone (c-hGH) developed biomarker changes in the realm of Alzheimer’s disease (AD). This study indicates the ...

The posterior pituitary is the smaller of two lobes that make up your pituitary gland. It secretes vasopressin and oxytocin into your bloodstream — hormones that play a role in water balance, ...

A study investigated pituitary dwarfism in Karelian Bear Dogs and found a link to a variant of the POU1F1 gene. The results can also help understand the gene's significance to the human pituitary ...

Researchers have developed the world's first congenital pituitary hypoplasia (CPH) model using patient-derived iPS cells. The research group succeeded in using the model to illuminate the mechanisms ...