Nature

Efficacy of very low dose perindopril 2 mg/indapamide 0.625 mg combination on left ventricular hypertrophy in hypertensive patients: the P.I.C.X.E.L. study rationale and design

This phase III, multicentre, international study is conducted in 60 echocardiographic centres located in nine countries (Austria, Belgium, France, Germany, Hungary, Italy, Russia, Spain, The ...
clinicaladvisor.com

PERINDOPRIL PLUS INDAPAMIDE REDUCES CARDIOVASCULAR MORTALITY IN TYPE 2 DIABETICS

A fixed combination of perindopril (an ACE inhibitor) plus indapamide (a diuretic), available under the brand name Preterax, was evaluated in a randomized trial (Lancet. 2007;370:829-840). Patients ...
Medscape

ADVANCE: Perindopril/indapamide for all type 2 diabetes patients?

For a follow-up discussion of the ADVANCE trial, see ADVANCE reinforces message to aggressively treat blood pressure in diabetics The study, which is being presented today at the European Society of ...
Nature

Further evidence for low-dose combinations in patients with left ventricular hypertrophy

The REASON trial is an international, multicentre, randomised, double-blind investigation with two parallel groups. 16, 17, 18, 19, 20 This trial compared the ...
Medscape

OPTIMAX: Real-life Rates of Blood Pressure Normalization With First-line Therapy

In contrast to the direction taken in the United States, the current guidelines of the European Society of Hypertension and the European Society of Cardiology (ESH/ESC) [1] endorse combination therapy ...