Scientists broadly agree that both apolipoprotein E and microglia are necessary ingredients for amyloidosis. In mice devoid of ApoE, or of their microglia, scant plaques form. Now, a sweeping study ...

Crystalline polymers assembled inside tumor cell lysosomes rupture membranes, release iron, and trigger immune-activating ...

Macrophages rely on lysosomes to balance microbial killing with self-protection, generating reactive oxygen and nitrogen species during phagocytosis. Using platinum nanoelectrodes, researchers at ...

Scientists have discovered how iron in lysosomes can induce ferroptosis, offering a new route to target treatment-resistant cancer cells and stop metastasis. Ferroptosis has been gathering an ...