A comprehensive atlas of the human hypothalamus, a brain region that regulates many bodily functions, including temperature, sleep and appetite, has been built using single-cell RNA sequencing and ...

Compared to sugar, consuming sucralose-a widely used sugar substitute-increases activity in the hypothalamus, a brain region that regulates appetite and body weight, according to a new USC study.

While small, the hypothalamus – a complex structure located deep in the brain – plays a gargantuan role in coordinating the wide array of neuronal signals that are responsible for keeping the body in ...

The widely used sugar substitute sucralose may affect “key mechanisms” in the brain’s hypothalamus responsible for appetite regulation, a small randomized crossover trial suggested. Compared with a ...

Researchers have discovered the mechanism by which a cluster of astrocytes, specialized brain cells, in the hypothalamus cause obesity in mice. Their study also identified a drug that inhibited the ...

Obesity is a global health problem that affects many people. In recent years, very promising anti-obesity drugs have been developed. Despite these successes, there are patients who do not respond to ...

An almond-shaped structure deep in the brain controls people's feelings of hunger and fullness in an attempt to keep them at a constant body weight. In obesity, its signaling can be disrupted. When ...