Emerging evidence suggests that hepatocytes are primarily maintained by self-renewal during normal liver homeostasis, as well as in response to a wide variety of hepatic injuries. However, how ...

Donor organ shortage is still the major obstacle for the clinical application of hepatocyte transplantation in the treatment of liver diseases. However, generation of hepatocyte-like cells from ...

Bone marrow contains stem cells with the potential to differentiate into mature cells of various organs. We determined whether circulating stem cells have a similar potential. Biopsy specimens from ...

Figure 1: a, rhTRAIL-induced cytotoxicity and apoptosis. Figure 3: RT–PCR analysis of the expression of TRAIL receptors in human liver tissue, human hepatocytes in culture, tumor cell line (HepG2), ...

In vitro drug-metabolism data has been increasingly utilized in understanding and predicting pharmacokinetics in vivo. Traditionally, predictive studies have been conducted in animal models. Because ...

Hepatocytes generated from iPSCs of different germ-layers secreted liver proteins into blood. Researchers have demonstrated that mature and immature liver cells generated from induced pluripotent stem ...

Induction of cytochrome P450 (CYP) by drugs is one of major concerns for drug-drug interactions. Thus, the assessment of CYP induction by novel compounds is a vital component in the drug discovery and ...

This article explores a number of frequently asked questions around working with plateable hepatocytes. It also outlines common reasons that hepatocyte plating fails, providing a range of potential ...

Hepatocytes are parenchymal cells that constitute as much as 80% of the total liver volume and mediate a number of vital liver functions, such as the control of lipid and carbohydrate homeostasis, the ...

Fluorescence microscopy image of a mouse liver tissue section marked with different fluorescent reporters. Local hepatocyte groups sharing the same reporter are of clonal origin. “Using spatial ...

In the latest installment of ADME 101, one of our hepatocyte experts answers frequently asked questions about plateable hepatocytes, discusses common reasons why hepatocyte plating fails and ...

In a new study published in the Journal of Hepatology, researchers from the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) show that only 15–20% of hepatocytes in newborn mice - dubbed ...