Cytoplasmic dynein is a vital microtubule-based motor protein that drives retrograde intracellular transport, supporting essential cellular functions ranging from organelle positioning to cell ...

The cell cytoskeleton is modulated by motor proteins, known as dyneins, that generate force and movement on microtubules to control a wealth of biological processes, including motility, cell division, ...

Researchers capture first-of-its-kind video of dynein–Lis1 protein interaction, supporting future drug development for neurological disorders. Our cells rely on microscopic highways and specialized ...

Researchers have uncovered the mechanism by which a protein facilitates the spread of breast cancer cells from the primary tumor into healthy tissue. The discovery not only improves our understanding ...

Understanding this motion may help to tackle health problems that affect cilia, which range from fertility issues to lung disease and COVID-19. Using cryo-electron tomography, researchers have ...

Motor proteins running the natural roadways on the skeletons of our cells are hauling cargo that is both essential to life and can cause disease, scientists say. They are working to learn just what ...

The paper A.K. Rai et al., “Molecular adaptations allow dynein to generate large collective forces inside cells,” Cell, 152:172-82, 2013. Inside every cell is a busy transit system, with motor ...