Medscape

Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive inhibitor of ...
Nature

Cyclooxygenase Modulation in Anti-Inflammatory Pharmacology

Cyclooxygenases (COX-1 and COX-2) lie at the heart of the inflammatory cascade, catalysing the conversion of arachidonic acid into bioactive prostaglandins that mediate pain, fever and vascular ...
TCTMD

COX-2-Selective NSAIDs a Better Choice in DOAC-Treated AF Patients

COX-2-selective nonsteroidal anti-inflammatory drugs (NSAIDs) appear to be a safer option than their nonselective counterparts among patients with atrial fibrillation (AF) who are taking a direct oral ...
News Medical

Some COX inhibitors/NSAIDs increase COVID-19 severity

A startling new preprint research paper posted to the medRxiv* server warns against the use of commonly used non-steroidal anti-inflammatory drugs (NSAIDs) belonging to the category of cyclooxygenase ...
Medscape

Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity

BAE: Bovine aortic endothelial; RHP: Recombinant human protein. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does ...