Understanding a drug’s mechanism of action (MOA) can greatly increase the likelihood of successful clinical trials by identifying biomarkers of patient response and providing a rationale for ...
Dynamic changes in chromatin drive gene expression programs during cellular development and contribute to pathological changes underlying disease. To date, efforts to characterize chromatin dynamics ...
Although many effective small molecule drugs are known to work by interacting with the genome, their underlying mechanism often remains unclear. Gaining an understanding of where and how small ...
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The first 3D mapping of the human genome
The genetic heritage is not a simple, static list inside the cell nucleus. It unfolds into a dynamic architecture whose ...
DURHAM, NC, November 11, 2025 / Biotech Newswire / -- EpiCypher®, a leader in chromatin biology and epigenetics, today announced the launch of its CUTANA® Fiber-seq Kit and the exclusive licensing of ...
(L to R) First author Kelly Barnett, Ph.D., and corresponding author Daniel Savic, Ph.D., both of the St. Jude Department Pharmacy and Pharmaceutical Sciences. (MEMPHIS, Tenn. – November 20, 2023) ...
From the Henikoff Lab, Cancer Basic Biology Program, Cancer Consortium. MulTI-Tag, or Multiple Target Identification by Tagmentation, builds upon the CUT&Tag technology developed by Dr. Hatice ...
Genomic DNA is organized into chromatin via nucleosomes, regulating its accessibility for critical biological processes such as transcription, replication, and epigenetic modification. The dynamic ...
National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into ...
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