Chaperone-mediated autophagy (CMA) contributes to regulation of energy homeostasis by timely degradation of enzymes involved in glucose and lipid metabolism. Here, we report reduced CMA activity in ...
Two related studies published today in Nature Metabolism show that a specialized intracellular recycling ...
Researchers decipher mechanism that prevents the loss of brown adipose tissue activity during ageing
From left to right, Tania Quesada-López, Francesc Villarroya, Albert Blasco-Roset, Marta Giralt, Alberto Mestres-Arenas, Joan Villarroya, Aleix Gavaldà-Navarro and Rubén Cereijo. As the body ages, ...
Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson’s disease protein
Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...
Researchers created a targeted fat loss therapy using light-sensitive nanoparticles that activate fat-burning processes inside adipocytes, offering a new direction for localized obesity treatment ...
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