Beijing Zhongke Journal Publising Co. Ltd. Congenital heart defects (CHDs) are the most common birth defects, occurring in approximately 0.9% of live births. Sadly, they are also the leading cause of ...

Fibroblasts are an essential component of the heart, as they play key roles in its structure, development and response to ...

New Approach Methodologies (NAMs) are revolutionizing disease modeling with human-based models that enhance predictive accuracy. iPSC-derived cardiac organoids lead this innovation, offering insights ...

Atrial septal defect (ASD) is a hole in the wall between the heart’s two upper chambers. ASD is a congenital heart defect, meaning it is present from birth. In some cases of ASD, a small hole may only ...

The same molecular pathway that is responsible for preventing adult heart cells from regenerating after being damaged - like after a heart attack - has been identified as involved in embryonic ...

Heart disease remains the leading cause of death worldwide, yet progress in understanding and treating cardiac disorders is limited by the shortcomings of existing experimental models. Traditional ...

An ostium primum atrial septal defect (ASD) occurs when then atrial septum near the atrioventricular valves has a communication between the two atrium causing a left to right shunt. This rarely ...

An atrial septal defect is an opening or hole in the wall that sits between the heart’s two upper chambers. The heart’s upper chambers are called the right and left atria. Some people refer to atrial ...

A broad spectrum of procedures ranging from basic diagnostic cardiac catheterization to transcatheter closure of atrial septal defects (ASDs) has progressed to the point where such techniques are ...

An atrial septal defect of the secundum type is relatively common and occurs from failure of the septum secundum to develop. This results in a communication between the left and right atrium directly ...

Adults born very preterm have increased cardiac mass and reduced function. We investigated whether a hypertrophic phenomenon occurs in later preterm infants and when this occurs during early ...