WR Kameron Johnson catches a 34-yard touchdown pass from QB Baker Mayfield against the San Francisco 49ers in Week 6 of the 2025 NFL season.

The injury report for the Tampa Bay Buccaneers (4-1) heading into their game against the San Francisco 49ers (4-1) features 11 players. The contest starts at 4:25 p.m. ET on Sunday, Oct. 12, at Raymond James Stadium. Game time: 4:25 p.m. ET

Anthony Richardson was inactive for Sunday's game against the Cardinals after sustaining an injury during pregame warmups, and according to ESPN's Stephen Holder, the Colts' backup quarterback will likely miss multiple games because of the incident. Richardson injured his eye while doing band work, according to NFL Network's Ian Rapoport.

Read below for the full injury report for both teams: WR Mike Evans (hamstring) - DNP (Wed.) NT Greg Gaines (pectoral) - DNP (Wed.)

Tampa Bay receiver and former Ohio State star Emeka Egbuka is expected to miss time with a hamstring injury, though the Buccaneers say it’s not serious.

The 49ers ruled out Brock Purdy for the fourth time this season and plan to have Mac Jones start Sunday’s visit to Tampa Bay.

The San Francisco 49ers released their latest injury updates headed into the Week 6 contest versus the Tampa Bay Buccaneers.

Mac Jones, already battered through three starts, was sacked six times and intercepted twice but threw for 347 yards with a sore oblique and knee. Coach Kyle Shanahan didn’t blame Jones for getting intercepted on the opening possession’s third down, seeing how Kendrick Bourne apparently turned the wrong way on his route.

Quarterback injuries throw everything for a loop in the NFL, and that's certainly been the case in the early stages of 2025. That remains the case for Week 6, but signal-callers aren't the only big injuries worth monitoring this weekend.