Muscarinic acetylcholine receptors (mAChRs) are central to the modulation of neurotransmission in the human brain and are emerging as promising targets in the management of neuropsychiatric disorders.

Mouse neuroblastoma cells (Clone NIE-115) were grown in serum-free (defined) medium, defined medium supplemented with serum, and control medium to determine whether serum-free medium could substitute ...

Asceneuron SA, an emerging leader in the development of innovative small molecules for neurodegenerative diseases, has been awarded a research grant from The Michael J. Fox Foundation for Parkinson’s ...

In the December 2 Nature Chemical Biology, researchers led by Jeffrey Conn at Vanderbilt University, Nashville, Tennessee, report that they have developed a small molecule that not only boosts the ...

Acetylcholine is a chemical messenger, or neurotransmitter, that plays an important role in brain and muscle function. Imbalances in acetylcholine are linked with chronic conditions, such as Alzheimer ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 2 (January 11, 2011), pp. 621-625 (5 pages) The nicotinic acetylcholine receptor of skeletal muscle is ...

BOSTON--(BUSINESS WIRE)--Karuna Pharmaceuticals, focused on targeting muscarinic receptors for the treatment of central nervous system (CNS) disorders including schizophrenia and Alzheimer’s Disease ...

Adam Feuerstein is a senior writer and biotech columnist, reporting on the crossroads of drug development, business, Wall Street, and biotechnology. He is also a co-host of the weekly biotech podcast ...

BOSTON--(BUSINESS WIRE)--Karuna Pharmaceuticals, focused on targeting muscarinic receptors for the treatment of disorders marked by psychosis and cognitive impairment, today announced the completion ...

Neurotransmitters are chemical messengers in the body. Their function is to transmit signals from nerve cells to target cells. These signals help regulate bodily functions ranging from heart rate to ...

Karuna Therapeutics and Bristol Myers Squibb are winners of the 2025 Gizmodo Science Fair for their research and development of Cobenfy (xanomeline-trospium), the first truly novel medication for ...